GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2028299 | 1 | rs6496609 | chr15:90379632 | C15orf38 | chr15:90443832-90456222:- | 0.35 | 7.33 | 9.74E-13 | Type 2 diabetes |
| THCA | cis | rs6496667 | 1 | rs6496665 | chr15:90891615 | IQGAP1 | chr15:90931473-91045475:+ | 0.13 | 4.28 | 2.23E-5 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496665 | chr15:90891615 | TTLL13 | chr15:90792764-90815443:+ | 0.2 | 3.77 | 0.000182 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496666 | chr15:90891662 | IQGAP1 | chr15:90931473-91045475:+ | 0.14 | 4.58 | 5.84E-6 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496666 | chr15:90891662 | TTLL13 | chr15:90792764-90815443:+ | 0.27 | 4.79 | 2.18E-6 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496667 | chr15:90893668 | IQGAP1 | chr15:90931473-91045475:+ | 0.13 | 4.2 | 3.14E-5 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496667 | chr15:90893668 | TTLL13 | chr15:90792764-90815443:+ | 0.19 | 3.49 | 0.000519 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496668 | chr15:90893704 | IQGAP1 | chr15:90931473-91045475:+ | 0.15 | 4.48 | 9.53E-6 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496668 | chr15:90893704 | TTLL13 | chr15:90792764-90815443:+ | 0.26 | 4.38 | 1.44E-5 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496669 | chr15:90895265 | IQGAP1 | chr15:90931473-91045475:+ | -0.13 | -4.28 | 2.22E-5 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs6496669 | chr15:90895265 | TTLL13 | chr15:90792764-90815443:+ | -0.25 | -4.4 | 1.34E-5 | Rheumatoid arthritis |
| THCA | cis | rs8042680 | 1 | rs6496743 | chr15:91528358 | HDDC3 | chr15:91474157-91475774:- | -0.15 | -4.18 | 3.44E-5 | Type 2 diabetes |
| THCA | cis | rs8040855 | 1 | rs6496768 | chr15:85702932 | LOC388152 | chr15:84867600-84898920:- | 0.24 | 4.25 | 2.6E-5 | Bulimia nervosa |
| THCA | cis | rs7200543 | 1 | rs6498540 | chr16:15130594 | NTAN1 | chr16:15131717-15149833:- | 0.13 | 3.73 | 0.000218 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs7200543 | 1 | rs6498540 | chr16:15130594 | PDXDC1 | chr16:15068599-15233195:+ | 0.32 | 7.49 | 3.32E-13 | Metabolic traits;Glycerophospholipid levels |